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In chemotherapy, cytostatics — i. This approach often leads to success but has a number of drawbacks. It has a negative effect on healthy cells, and may also cause significant side effects in some patients. This makes it difficult to choose the right substances for further treatment. Microscopic image of tumor cells in which Ezh2 activity is inhibited red within a mouse lung and surrounded by immune cells green.
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In chemotherapy, cytostatics — i. This approach often leads to success but has a number of drawbacks. It has a negative effect on healthy cells, and may also cause significant side effects in some patients. This makes it difficult to choose the right substances for further treatment. Microscopic image of tumor cells in which Ezh2 activity is inhibited red within a mouse lung and surrounded by immune cells green. In a certain form of non-small cell lung cancer, the chemotherapy frequently results in altered cancer cells that are almost untreatable.
Those developing new treatments must keep this possibility in mind. Together with his team and researchers under Professor Maarten van Lohuizen of the Netherlands Cancer Institute in Amsterdam , he has tested how this might work on mice that were injected with cells of a special form of non-small cell lung cancer. In this form of non-small cell lung cancer, the cancer cells produce large quantities of an enzyme called Ezh2. The enzyme represses a number of tumor suppressor genes, which normally stop cells from multiplying out of control.
Agents that inhibit this enzyme and thus reactivate the tumor suppressor genes are currently being tested in clinical studies. But the researchers had also expected the agent to lose its effect over time. The remaining cancer cells thus became even more aggressive as a result of the treatment. This is precisely where the MDC researchers are focusing their efforts. They are intentionally sending the tumor cells down this path — and setting them up for a trap. However, it is still a long way to go before patients will see benefits from these new treatment strategies.
Michela Serresi et al. Michela Serresis web page. The MDC's mission is to study molecular mechanisms in order to understand the origins of disease and thus be able to diagnose, prevent and fight it better and more effectively. More than 1, staff and guests from nearly 60 countries work at the MDC, just under 1, of them in scientific research.
In rat kidney cells, green-labelled aquaporin AQP2 partially migrates to the cell surface as soon as it is stimulated by the drug forskolin. Cell nuclei appear red. Chess and cancer research have one thing in common: One must act strategically to defeat the opponent. They are seeking to selectively make only those cancer cells aggressive that would otherwise evade chemotherapy — and then lure them into a trap.
Gargiulo Lab Molecular Oncology. Press Release No. This completes the first round of baseline examinations. The pan-European research initiative aims to develop new technologies for the treatment and early detection of diseases. The MDC aims to reduce the number of animals used in research, to minimize animal suffering, and to use alternative methods as much as possible in its pursuit of medical knowledge.
However, research still requires the use of animal studies. An MDC research team has discovered surprising new properties in fluconazole, a long approved fungal drug. The substance helps to draw water from urine. The researchers found this in rodents. The fungicide could help patients with rare genetic diseases in whom the water transport of the kidneys is impaired.
Nevertheless, the path to therapy is not easy.
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